The Muscle Relaxants in Anaesthesia

The Use of Muscle Relaxants in Infants and Children.

The belief that the use of muscle relaxants in infants and children is both unnecessary and dangerous has not been substantiated by subsequent clinical experience. The important advances that have been made recently in paediatric anaesthesia are due largely to the introduction of muscle relaxants, which have reduced the need for toxic agents to a minimum and have emphasized the importance of co...

The estimation and comparison of histamine release by muscle relaxants in man.

Experimental central nervous system studies related to anaesthesia: clinical implications. 3. Effects of muscle relaxants on sensory inflow.

REPORTS OF PATIENTS regaining consciousness during surgical anaesthesia continue to occur. 1 In these circumstances anaesthesia usually is maintained by the simultaneous use of eurarization, controlled ventilation, and a light general anaesthetic; a lighter plane of anaesthesia can thereby be used and good muscle relaxation achieved. However, the influences which curariT.ing drugs may exert on ...

Awareness, muscle relaxants and balanced anaesthesia.

The incidence of awareness during insufficient anaesthesia is reported to be one per cent. It is usually due to the use of muscle relaxants, a balanced technique and the lightest possible depth of anaesthesia. Increased incidences were noted in open-heart surgery, during intubation-endoscopy procedures and in caesarean delivery patients. Experiences of awareness are disturbing to patients, who ...

EFFECTS OF CHRONIC ADMINISTRATION OF TWO NEWLY SYNTHESIZED NONDEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS

The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...

Complications of anaesthesia in neuromuscular disorders.

The purpose of this review is to alert non-anaesthesiologists to the various complications from which patients with neuromuscular disorders and those susceptible to malignant hyperthermia can suffer during anaesthesia. The patient's outcome correlates with the quality of consultation between anaesthesiologists, surgeons, neurologists and cardiologists. Special precautions must be taken, since m...